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pentobarbital will decrease the level or result of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital will lessen the level or effect of meloxicam by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Importance Unidentified.pentobarbital will lessen the level or effect of tramadol by impac